A shame his comparison is meaningless and misleading. The difference between the pixel density of a small compact camera and a Canon with a 35mm sized sensor is huge, whereas the difference between the S2 and D800 isn't. Indeed some have queried whether the S2 can be classified as medium-format anyway.
S2 - 37.5 MP 30x45mm
D800 36MP - 24x36mm.
The mistake here is surely that basically patronising potential customers (and therefore buyers) of the camera only reinforces Leica's (unjustified) reputation as the creator of rich peoples playthings.
Now whatever the merits of the S system over a DSLR such as the D800, the reason why the Nikon is getting so much attention is how the costs stack up.
Lets look at the current S2 system.
Body - Around the £17,500 mark
24mm f/3.5 £5,300
35mm f/2.5 £4,500
70mm f/2.5 £3,400
120mm f/2.5 £5,000
30-90mm Zoom £7,300
180mm f/3.5 £5,000
The D800 can currently be bought in the UK for around £2,300. Lenses - well the choice is huge at all prices and all specifications.
In the current recession, professional photographers working in the commercial field have to offer what their clients perceive as value for money. Assuming that they can afford the S2 and some lenses in the first place, or indeed afford the cost of hiring such an outfit on a regular basis, they then would have to make that back, before they turn a profit. There are still obviously in-demand photographers to whom that isn't a problem, but I suspect that there are less of those than there used to be. When offering a price to a client, its obvious that the D800 user has an advantage, in that they aren't trying to recoup the considerable costs that the S2 owner has.
Now as I said, I'm not going into the S2 v D800 quality debate, other than to say that having run some S2 raw files through Photoshop, I saw nothing that changes my opinion about the D800 / D800E. Plus any differences that there might be are really not going to be that huge. I'm also not going to go into the differences between the two in terms of handling, versatility and the ability to use the cameras in wide variety of situations, as I think its pretty obvious which camera has the advantage there.
Nothing to do with Leica, but if you want to see an interesting video on the D800 compared to MF (Not the S2), I've included one put out by The Camera Store below.